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Natural killer cell lines in tumor immunotherapy

Min Cheng, Jian Zhang, Wen Jiang, Yongyan Chen, Zhigang Tian

Frontiers of Medicine 2012, Volume 6, Issue 1,   Pages 56-66 doi: 10.1007/s11684-012-0177-7

Abstract:

Natural killer (NK) cells are considered to be critical players in anticancer immunity.However, cancers are able to develop mechanisms to escape NK cell attack or to induce defective NK cellsCurrent NK cell-based cancer immunotherapy is aimed at overcoming NK cell paralysis through several potentiallines and genetically modifying fresh NK cells or NK cell lines.In this review, NK cells in tumor immunotherapy are discussed, and a list of therapeutic NK cell lines

Keywords： natural killer cell     natural killer cell line     tumor immunotherapy     genetic modification    

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Natural killer cells in liver diseases

Meijuan Zheng, Haoyu Sun, Zhigang Tian

Frontiers of Medicine 2018, Volume 12, Issue 3,   Pages 269-279 doi: 10.1007/s11684-018-0621-4

Abstract: The liver contains a large proportion of natural killer (NK) cells, which exhibit heterogeneity in phenotypicNK cell activation, well known for its role in the immune surveillance against tumor and pathogen-infectedIn addition to the innate direct “killer” functions, NK cell activity contributes to regulateHere, we focus on the relationship between NK cell biology, such as their phenotypic features and functional

Keywords： natural killer cell     phenotype     immune activation     immune tolerance     liver diseases    

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Natural killer cells in hepatocellular carcinoma: current status and perspectives for future immunotherapeutic

Min Yu, Zonghai Li

Frontiers of Medicine 2017, Volume 11, Issue 4,   Pages 509-521 doi: 10.1007/s11684-017-0546-3

Abstract: the liver and in the immune defenses against HCC, indicating that HCC might be an ideal target for NK cell-basedpaper summarizes current knowledge on NK cells in HCC and discusses the usefulness and prospects of NK cell-basedCritical issues that require consideration for the successful clinical translation of NK cell-based therapiesIf appropriately used and further optimized, NK cell-based therapies could dominate important roles in

Keywords： natural killer cell     hepatocellular carcinoma     immunotherapy    

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Astragaloside IV suppresses post-ischemic natural killer cell infiltration and activation in the brain

Baokai Dou, Shichun Li, Luyao Wei, Lixin Wang, Shiguo Zhu, Zhengtao Wang, Zunji Ke, Kaixian Chen, Zhifei Wang

Frontiers of Medicine 2021, Volume 15, Issue 1,   Pages 79-90 doi: 10.1007/s11684-020-0783-8

Abstract: Natural killer (NK) cells, a type of cytotoxic lymphocytes, can infiltrate into ischemic brain and exacerbateneuronal cell death.Strikingly, ASIV reversed NK cell deficiency in the spleen and blood after brain ischemia.Meanwhile, ASIV attenuated NK cell activating receptor NKG2D levels and reduced interferon-γ productionFurthermore, ASIV’s effects on suppressing NK cell brain infiltration and activation may involve HDAC

Keywords： astragaloside IV     brain ischemia     natural killer cells     histone deacetylase     nuclear factor-κB    

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Natural Killer Cell-Based Immunotherapy for Cancer: Advances and Prospects Review

Yuan Hu, Zhigang Tian, Cai Zhang

Engineering 2019, Volume 5, Issue 1,   Pages 106-114 doi: 10.1016/j.eng.2018.11.015

Abstract:

Natural killer (NK) cells are key innate immune cells that provide the first line of defense againsttransformed cells and malignancies in real time, tumors develop several strategies to escape from NK cellincluding autologous or allogeneic NK cells, umbilical cord blood (UCB) or induced pluripotent stem cellIn this review, we summarize the mechanisms of tumor escape from NK cell recognition, the current statusand advanced progress of NK cell-based immunotherapy, ways of enhancing the antitumor capacity of NK

Keywords： Natural killer cell     Immunotherapy     Cancer     Clinical trial     Chimeric antigen receptor    

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Challenges of NK cell-based immunotherapy in the new era

Fang Fang, Weihua Xiao, Zhigang Tian

Frontiers of Medicine 2018, Volume 12, Issue 4,   Pages 440-450 doi: tzg@ustc.edu.cn

Abstract:

Natural killer cells (NKs) have a great potential for cancer immunotherapy because they can rapidlyVarious cellular sources, including peripheral blood mononuclear cells (PBMCs), stem cells, and NK cellHowever, considering the safety, activities, and reliability of the cell products, researchers must developIn this review, the challenges on NK cell-based therapeutic approaches and clinical outcomes are discussed

Keywords： natural killer cells     immunotherapy     adoptive transfer     genetic modification     immune checkpoint inhibitor    

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Study of recombinant human IFN-α-2b bacilli Calmette–Guerin activated killer cells and against bladdercancer cell in vitro

FAN Xiaodong, HAN Ruifa

Frontiers of Medicine 2007, Volume 1, Issue 4,   Pages 377-380 doi: 10.1007/s11684-007-0073-8

Abstract: monocytes (PBMC) were stimulated by recombinant BCG and transformed into bacilli Calmette–Guerin activated killer

Keywords： Urology     powerful     2b-BCG     Tianjin institute     wild-type    

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NKT cells in liver diseases

Shasha Zhu, Huimin Zhang, Li Bai

Frontiers of Medicine 2018, Volume 12, Issue 3,   Pages 249-261 doi: 10.1007/s11684-018-0622-3

Abstract:

Natural killer T cells are innate-like and tissue-resident lymphocytes, which recognize lipid antigensNatural killer T cells play important roles in infections, tumors, autoimmune diseases, and metabolicIn this study, we summarize recent findings on biology of natural killer T cells and their roles in hepatitiskiller T cells during the progression of liver diseases, which might be caused by changes in naturalkiller T subsets, factors skewing cytokine responses, and intercellular crosstalk between natural killer

Keywords： natural killer T cells     hepatitis B virus and hepatitis C virus infection     autoimmune liver diseases     alcoholic    

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Research on the theory and application of adsorbed natural gas used in new energy vehicles: A review

Zhengwei NIE,Yuyi LIN,Xiaoyi JIN

Frontiers of Mechanical Engineering 2016, Volume 11, Issue 3,   Pages 258-274 doi: 10.1007/s11465-016-0381-2

Abstract:

Natural gas, whose primary constituent is methane, has been considered a convincing alternative forAdsorbed natural gas (ANG), the most promising methane storage method, has been an active field of studyANG constitutes a safe and low-cost way to store methane for natural gas vehicles at an acceptable energy

Keywords： adsorbed natural gas (ANG)     adsorbent     adsorption theory     conformable tank     natural gas vehicles (NGVs)    

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Effects of natural zeolite and sulfate ions on the mechanical properties and microstructure of plastic

Frontiers of Structural and Civil Engineering 2022, Volume 16, Issue 1,   Pages 86-98 doi: 10.1007/s11709-021-0793-x

Abstract: Natural zeolite (NZ) is a relatively abundant mineral resource and in this research, the microstructure

Keywords： plastic concrete     sulfate resistance     natural zeolite     triaxial compression test     SEM     permeability    

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A review on technologies with electricity generation potentials using liquified natural gas regasification

Frontiers in Energy 2023, Volume 17, Issue 3,   Pages 332-379 doi: 10.1007/s11708-023-0863-y

Abstract: In such scenarios, the effective and efficient utilization of the liquified natural gas (LNG) regasification

Keywords： liquified natural gas     cold energy     power generation    

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Accelerating the construction of natural gas system engineering in green smart cities

Xinhua MA

Frontiers of Engineering Management 2019, Volume 6, Issue 3,   Pages 453-456 doi: 10.1007/s42524-019-0046-z

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New nanostructured sorbents for desulfurization of natural gas

Lifeng WANG, Ralph T. YANG

Frontiers of Chemical Science and Engineering 2014, Volume 8, Issue 1,   Pages 8-19 doi: 10.1007/s11705-014-1411-4

Abstract: Desulfurization of natural gas is achieved commercially by absorption with liquid amine solutions.

Keywords： desulfurization     natural gas desulfurization     hydrogen sulfide sorbent     amine-silica sorbent    

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Dehydration of natural gas and biogas streams using solid desiccants: a review

Soheil Bahraminia, Mansoor Anbia, Esmat Koohsaryan

Frontiers of Chemical Science and Engineering 2021, Volume 15, Issue 5,   Pages 1050-1074 doi: 10.1007/s11705-020-2025-7

Abstract: Natural gas and biogas are two mixtures that consist of methane as their main component.

Keywords： natural gas     biogas     dehydration     adsorption     solid desiccant    

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2019 highlights of the structural revision of natural product

Zongjia Chen, Mark A. Rizzacasa

Frontiers of Chemical Science and Engineering 2021, Volume 15, Issue 3,   Pages 595-601 doi: 10.1007/s11705-020-1971-4

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Title Author Date Type Operation

Natural killer cell lines in tumor immunotherapy

Min Cheng, Jian Zhang, Wen Jiang, Yongyan Chen, Zhigang Tian

Journal Article

Natural killer cells in liver diseases

Meijuan Zheng, Haoyu Sun, Zhigang Tian

Journal Article

Natural killer cells in hepatocellular carcinoma: current status and perspectives for future immunotherapeutic

Min Yu, Zonghai Li

Journal Article

Astragaloside IV suppresses post-ischemic natural killer cell infiltration and activation in the brain

Baokai Dou, Shichun Li, Luyao Wei, Lixin Wang, Shiguo Zhu, Zhengtao Wang, Zunji Ke, Kaixian Chen, Zhifei Wang

Journal Article

Natural Killer Cell-Based Immunotherapy for Cancer: Advances and Prospects

Yuan Hu, Zhigang Tian, Cai Zhang

Journal Article

Challenges of NK cell-based immunotherapy in the new era

Fang Fang, Weihua Xiao, Zhigang Tian

Journal Article

Study of recombinant human IFN-α-2b bacilli Calmette–Guerin activated killer cells and against bladdercancer cell in vitro

FAN Xiaodong, HAN Ruifa

Journal Article

NKT cells in liver diseases

Shasha Zhu, Huimin Zhang, Li Bai

Journal Article

Research on the theory and application of adsorbed natural gas used in new energy vehicles: A review

Zhengwei NIE,Yuyi LIN,Xiaoyi JIN

Journal Article

Effects of natural zeolite and sulfate ions on the mechanical properties and microstructure of plastic

Journal Article

A review on technologies with electricity generation potentials using liquified natural gas regasification

Journal Article

Accelerating the construction of natural gas system engineering in green smart cities

Xinhua MA

Journal Article

New nanostructured sorbents for desulfurization of natural gas

Lifeng WANG, Ralph T. YANG

Journal Article

Dehydration of natural gas and biogas streams using solid desiccants: a review

Soheil Bahraminia, Mansoor Anbia, Esmat Koohsaryan

Journal Article

2019 highlights of the structural revision of natural product

Zongjia Chen, Mark A. Rizzacasa

Journal Article